Kisoro is approximately 76 kilometres (47 mi) west of Kabale, the largest city in the Kigezi sub-region.^[2] This is approximately 484 kilometres (301 mi), by road, southwest of Kampala, the capital of Uganda and the country's largest city.^[3] Kisoro is east of Rumangabo and the Virunga Mountains in the Democratic Republic of the Congo (DRC). The geographical coordinates of Kisoro are 1°17'06.0"S, 29°41'06.0"E (Latitude:-1.2850; Longitude:29.6850).^[4] Kisoro Town Council sits at an average elevation of 1,929 metres (6,329 ft), above mean sea level.^[5]

Kisoro is located under the peaks of the Mufumbiro Mountains, which are part of the Virunga Mountains and home to rare mountain gorillas. The area boasts of mountain scenery, Lake Mutanda, colorful markets, and volcano trekking. It is the nearest town to the Mgahinga Gorilla National Park and is an access town for those traveling to Rwanda or the DRC for gorilla tracking in the Volcanoes National Park or the Virunga National Park.^[6]